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The prevalence of noncompliant hypothyroid patients has been reported to be between 30% and 80% () despite the simplicity of l-T 4 replacement therapy and its once-daily oral administration.

Sorafenib has been associated with TSH elevations in about 18% of patients with metastatic renal cell carcinoma and in 33% of patients with thyroid carcinoma ().

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Given that no increased risk of congenital abnormalities have been demonstrated in pregnant women taking levothyroxine, therapy should be continued during pregnancy.

PDE8B gene and thyroid hormone parameters, including assessment of longitudinal stability of associations over time and effect of thyroid hormone replacement.

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The addition of T 3 to T 4 monotherapy should be restricted to persistently symptomatic hypothyroid patients despite their biochemical euthyroidism during l-T 4 replacement therapy with the goal of achieving improved QOL.

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Some degree of regrowth of nodules sometimes occurs after the cessation of l-T 4 therapy.

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However, these studies did not differentiate between the beneficial effects of TSH suppression according to the aggressiveness of DTC.

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Children born from mothers with prolonged hypothyroxinemia living in iodine-deficient areas may have a deficit of motor and mental development and an increased incidence of attention deficit disorder, hyperactivity disorder, and reduced IQ with a higher risk of expressive language delay and nonverbal cognitive delay compared with controls ().

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Although this experimental observation cannot be extrapolated to humans without the usual caveats, some studies have reported that low serum FT 3 and significantly higher serum FT 4 levels can be observed in thyroidectomized patients receiving l-T 4 replacement therapy ().

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Treatment of isolated hypothyroxinemia.

Although the degree of cardiovascular risk associated with SHypo remains controversial, some clarity may be gleaned from the various meta-analyses that have critically evaluated the results of all of the available prospective studies () ().

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