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So far, not been long-term randomized controlled trials with other drugs for HRT to detect a positive effect on morbidity and mortality related to CAS.

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There is no question that at present the triple drug combination represents the most effective regimen in self-injection therapy, which was also preferred over alprostadil in the cited trial.

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Metabolized primarily in the liver and partially in the intestine, kidney, skeletal muscle and the target organs with the formation of estrone, estriol, kateholestrogenov, as well as sulfate and glyukuronidnyh conjugates of these compounds with a substantially lower estrogenic activity or pharmacologically inactive.

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