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The gene disrupted in AS, UBE3A, is unique because its action is controlled by a remote DNA region that is called the imprinting center(IC).

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Mechanisms used to describe the therapeutic effect of immunotherapy include microgliamediated removal of betaamyloid, removal by the peripheral betaamyloid sink, and antibodymediated disaggregation of betaamyloid.

Advising additional contraceptive precautions for those taking combined hormonal contraceptives CHCs while taking a nonenzyme inducing antibiotic is no longer advocated.

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Amy Schalet, an associate professor of sociology at the University of Massachusetts Amherst who studies teen sexuality, praised the study and said it shows that the issues at stake for younger kids are different than for older ones.

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Carbamazepine is an inducer of CYP3A4 and Pgp and likely was responsible for the reduced plasma concentrations of rivaroxaban and the lack of DOAC efficacy seen in this patient.

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Grant Support: Development of the providerfacing Web tool that uses the results of this study was supported by a grant from the Veterans Affairs Quality Enhancement Research Initiative QUE 15286.

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