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Why are ACE inhibitors used in diabetic nephropathy? ACE inhibitors improve diabetic nephropathy through suppression of renal MCP-1. OBJECTIVE: Chemokines play an important role in the pathogenesis of diabetic nephropathy. Angiotensin II induces several fibrogenic chemokines, namely monocyte chemoattractant protein-1 (MCP-1) and transforming growth factor-beta.
How does diabetes mellitus affect the kidneys? If you have diabetes, your blood glucose, or blood sugar, levels are too high. Over time, this can damage your kidneys. If they are damaged, waste and fluids build up in your blood instead of leaving your body. Kidney damage from diabetes is called diabetic nephropathy.
What happens if you don't take your diabetes medication? If type 2 diabetes goes untreated, the high blood sugar can affect various cells and organs in the body. Complications include kidney damage, often leading to dialysis, eye damage, which could result in blindness, or an increased risk for heart disease or stroke.
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