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Compared with the individual components, the once-daily tiotropium plus formoterol treatment performed significantly better during the first 12-h period after inhalation of the morning dose.
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Adverse events and medications were reviewed at each study visit.
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The typical COPD patient is a current or former smoker, over age 50, with a pack-a-day habit of more than 20 years.
When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below.
If you are using Foradil to prevent exercise-induced asthma, use the medicine 15 minutes before exercising, or as directed by your doctor.
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However, this relatively weaker efficacy of salmeterol in comparison with formoterol, has not been objectively evaluated in asthmatic patients.
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The coupling of mAChRs to their cellular effector systems is mediated via heterotrimeric G proteins.
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The study was divided into three periods: Period 1 (study entry to end of first month), Period 2 (second and third months) and Period 3 (remainder of study).
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Include a valid prescription for your AstraZeneca medicine(s) from your doctor.
If this approach does not control the symptoms, the patient is recommended to have maintenance therapy with ICS.
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The use of beta-agonists and the risk of death and near death from asthma.
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Comparison of Oral Bambuterol and Inhaled Salmeterol in Patients with Symptomatic Asthma and Using Inhaled Corticosteroids.
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Predicting risk of airflow obstruction in primary care: Validation of the lung function questionnaire (LFQ).
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Oral steroids are as effective as injected steroids, provided tablets can be swallowed and retained and the patient does not become drowsy or begin to vomit.
S)-enantiomers represented about 40% and 60% of unchanged drug excreted in the urine, respectively, following single inhaled doses between 12 and 120 mcg in healthy volunteers and single and repeated doses of 12 and 24 mcg in patients with asthma.
Do not initiate in patients with significantly worsening or acutely deteriorating asthma; reports of severe (sometimes fatal) respiratory events have been reported when formoterol has been initiated in this situation.
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Considering the evidence for poor asthma control prior to the study, a mean daily dose of 448 μg would seem more appropriate than 252 μg, and is approximately the dose prescribed in the control group.
The majority of patients in each treatment group were prescribed ICS (63.
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The reduction in relative risk with respect to first exacerbation with formoterol versus salbutamol by category.
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The usual dose is 2 inhalations twice each day, morning and evening.
If the child does not adequately improve within or after the initial period, urgent medical care is recommended.
Talk with your healthcare provider about the risks and benefits of using Asmanex during pregnancy (see for more information).
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Combination Therapy for Asthma and Chronic Obstructive Pulmonary Disease, Marcel Dekker, Inc.
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The results show that RV infection stimulated CXCL10 secretion and an antiviral response as indicated by induction of IFNB1 and IL28 mRNA.
As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the drugs and foods mentioned above.
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In addition, the rate of exacerbations among patients in the tiotropium group who were receiving inhaled glucocorticoids at baseline but did not continue receiving them during the study-treatment period was not higher than the rate among those who were receiving inhaled glucocorticoids at baseline and continued to receive them during the study-treatment period.
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Yoga, which uses stretching, breathing, and meditation techniques, may have particular benefits.
In the safety substudy, there were no significant differences in bone mineral density or in the numbers of patients in whom cataracts developed between the groups receiving active study drugs and the placebo group ().
All animal manipulations were made in accordance with the European Community guidelines for the use of laboratory animals.
Inform patients that orally inhaled corticosteroids, including mometasone, may cause a reduction in growth velocity when administered to children.
Tissue Inhibitor of Metalloproteinase-1 Ratio Correlates with Steroid Responsiveness in Moderate to Severe Asthma.
Where does current and future pediatric asthma treatment stand?
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The lowest doses of all three drugs produced FEV 1 responses near the top of the dose-response curve, whereas systemic effects did not occur until after eight puffs.
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The condition can be present for more than five years before the patient recognizes any symptoms, and usually, rheumatoid arthritis affects the joints first.
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Outcome of myocardial infarction in patients treated with aspirin is enhanced by pre-hospital administration.
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These changes may result from exposure to cigarette smoke, use of tobacco products, and the release of inflammatory medicators.
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Unlike (EPO), which directly stimulates the production of red blood cells, FG-4592 is taken orally, and stimulates natural production of EPO in a manner similar to altitude training.
There is evidence that mAChR antagonists may be effective against EIA in some patients, but not usually in the majority ().
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In contrast, interferon responses were positively related to viral replication in our study, and the lower interferon responses observed in the asthma group were associated with a trend for lower viral replication.
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The maximum benefit may not be achieved for 1 week or longer after beginning treatment.
There is insufficient evidence to determine whether or not anti-depressants provide incremental benefits on cessation beyond that achieved by NRT alone.
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