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When Omeprazole and Sodium Bicarbonate is administered 1 hour after a meal, the omeprazole AUC is reduced by approximately 24% relative to administration 1 hour prior to a meal.

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Our own resident pharmacist, Scott Gavura, here on SBM a year ago. Their points are worth emphasizing and expanding upon.

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Absolute bioavailability (compared with intravenous administration) is about 30% to 40% at doses of 20 mg to 40 mg, due in large part to presystemic metabolism.

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