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Because the use of taurine supplementation varied between the study institutions (initially, some of the institutions used PN containing taurine and some did not), the decision was made a priori to additionally examine the effect of taurine supplementation on the development of PNAC.

Of particular interest is the very low incidence of diarrhoea (about 2%) compared with an incidence of up to 50% with therapeutic doses of chenodeoxycholic acid.

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For the biopsy, the doctor will withdraw a small sample of cells from the liver.

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If gallstones appear to have dissolved, Ursodiol therapy should be continued and dissolution confirmed on a repeat ultrasound examination within 1 to 3 months.

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Subjects were studied as in-patients during the period that samples were collected.

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